Causes of Persistent Fatigue You Should Not Ignore

Posted on: February 17, 2026 | Written By: Sanjeevani Team

5 Reasons for Persistent Fatigue

What is the Meaning of Fatigue?

Before we can fix it, we must understand it. So, what is the meaning of fatigue in a medical context? While we use the word “tired” casually, fatigue is a more intense, relapsing, or persistent sense of tiredness. It can be denoted by lack of energy physically and mentally.

Unlike the sleepiness you feel after a late-night movie, persistent fatigue is a “battery drain” that doesn’t recharge easily. You might feel weak, “heavy,” or “slowed down.” In many cases, it is a symptom of an underlying condition—your body’s way of saying it is struggling to maintain its internal balance.

Key Takeaways

  • Persistent fatigue is a clinical state of exhaustion that does not improve with rest and often interferes with daily life, unlike normal tiredness, which follows exertion.
  • Hidden medical triggers such as anemia, thyroid imbalances, and sleep apnea are common causes of chronic fatigue that require professional diagnostic testing.
  • Early intervention by a general medicine doctor is essential to rule out serious conditions and to begin effective chronic fatigue syndrome treatment if necessary.
Causes of Persistent Fatigue You Should Not Ignore

Recognizing the Red Flags: Fatigue Symptoms You Should Know

How do you distinguish between “I had a long day” and “Something is wrong”? Our specialists at Eskag Sanjeevani look for specific fatigue symptoms that act as red flags. If you notice these, your fatigue has likely crossed into the medical territory:

  • Brain Fog: You find it hard to concentrate, follow conversations, or remember simple tasks.
  • Unrefreshing Sleep: You wake up feeling just as exhausted as when you went to bed.
  • Post-Exertional Malaise (PEM): A sudden “crash” in energy 12–48 hours after even minor physical or mental activity.
  • Physical Heaviness: A feeling like your limbs are made of lead.
  • Mood Changes: Persistent irritability or a sudden loss of interest in hobbies you once loved.

If these fatigue symptoms linger for more than two weeks, your first step should be a visit to a general medicine doctor.

The Hidden Culprits: Common Causes of Chronic Fatigue

Exhaustion seems a casual thing, but it is usually a messenger. Identifying the causes of chronic fatigue needs looking beneath the surface.
Here are the most frequent triggers our experts diagnose:

1. Nutritional and Vitamin Deficiencies

In India, and particularly among women in Bengal, iron deficiency (anemia) is a leading cause. When your body lacks iron, your blood can’t carry enough oxygen to your tissues, leaving you breathless and drained. Similarly, low levels of Vitamin D and B12—common in urban dwellers—can lead to severe persistent fatigue.

2. Thyroid and Hormonal Imbalances

Your thyroid gland is your body’s energy regulator. If it is underactive (hypothyroidism), your metabolism slows to a crawl, leading to weight gain and lethargy. Conversely, an overactive thyroid can wear you out by keeping your body in “overdrive.”

3. Undiagnosed Sleep Apnea

Snoring or waking up gasping is a sign of sleep apnea.

Sleep apnea is a condition where your breathing repeatedly stops during the night. This prevents you from reaching deep sleep, causing profound persistent fatigue during the day.

4. Diabetes and Blood Sugar Fluctuations

When your body struggles to manage glucose, your cells don’t get the energy they need. This “starvation” at a cellular level is one of the classic causes of chronic fatigue.

5. Mental Health and Stress

Chronic stress keeps your body in a constant state of “fight or flight.” Over time, this drains your adrenal reserves and leads to burnout. Depression and anxiety also manifest as physical exhaustion, making even getting out of bed feel impossible.

When Energy Doesn’t Return-
Chronic Fatigue Syndrome Treatment

For a small percentage of people, the exhaustion is so severe it lasts for six months or more without an identifiable secondary cause. This is a complex condition where chronic fatigue syndrome treatment becomes necessary.

Unlike a standard cold, there is no single “cure” for this. Instead, chronic fatigue syndrome treatment focuses on:

  • Energy Management (Pacing): Learning to balance activity and rest to avoid the “boom and bust” cycle.
  • Symptom-Specific Care: Using medications to manage the pain or sleep issues that often accompany the condition.
  • Sleep Hygiene: Maintaining strict routines to maximize the quality of the rest you do get.

At Eskag Sanjeevani, we take a holistic approach, involving nutritionists, physiotherapists, and a general medicine doctor to help you manage this journey.

How Eskag Sanjeevani Supports Your Recovery?

You don’t have to navigate this fog alone. Our department of general medicine acts as a diagnostic hub. When you consult a general medicine doctor at our Kolkata units, we don’t just tell you to “take a holiday.” We investigate.

  • Comprehensive Screening: We offer detailed blood panels to check your thyroid, iron, B12, and blood sugar levels.
  • Cardiac Evaluation: Sometimes, persistent fatigue is a silent sign of heart issues. Our cardiologists are available for immediate consultation.
  • Home Sample Collection: If you are too tired to travel, our lab technicians can collect samples from the comfort of your home.

Stop Guessing, Start Healing with Eskag Sanjeevani Hospitals

Tiredness is a part of life, but persistent fatigue is not. If you are constantly canceling plans, struggling at work, or feeling like your “inner battery” is permanently low, it is time to seek answers.

By understanding what is the meaning of fatigue and identifying your specific fatigue symptoms, you take the first step toward reclaiming your spark. Whether the cause is a simple vitamin fix or a need for specialized chronic fatigue syndrome treatment, the experts at Eskag Sanjeevani are here to guide you.

Don’t ignore the whispers of your body.

Book a consultation with a general medicine doctor today and start your journey back to vitality.

Frequently Asked Questions on: Causes of Persistent Fatigue You Should Not Ignore
Is persistent fatigue different from being sleepy?

Yes. Being sleepy means you feel the need to sleep, and a nap usually helps. Persistent fatigue is a deep sense of exhaustion that doesn’t necessarily improve with rest.

How long should I wait before seeing a doctor for my exhaustion?

If your persistent fatigue lasts for more than two weeks and is affecting your work or family life, you should consult a general medicine doctor.

What tests are usually done to find the causes of chronic fatigue?

A doctor will likely order a Complete Blood Count (CBC), Thyroid Profile (TSH), Blood Sugar tests, and checks for Vitamin D and B12 levels.

Can my heart health be related to my fatigue symptoms?

Absolutely. If your heart isn’t pumping efficiently, your muscles don’t get enough oxygen, which can manifest as constant persistent fatigue.

Is chronic fatigue syndrome treatment lifelong?

Not necessarily. Many patients see significant improvement through “pacing,” lifestyle adjustments, and targeted symptom management over time.

Can stress really cause such severe persistent fatigue?

Yes. Chronic mental stress triggers physical responses that can lead to adrenal exhaustion and a significantly weakened immune system.

Does Eskag Sanjeevani offer full-body checkups for fatigue?

Yes, we have specialized diagnostic packages designed to identify the most common medical causes of chronic fatigue.

How do I book an appointment at the Eskag Sanjeevani Baghbazar unit?

You can call our helpline at 8100984046 or visit our website to book a session with an expert general medicine doctor.


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